Building on the milestones of QSP Summit 2025, this dedicated Day 2 track showcases how Quantitative Systems Pharmacology (QSP) is an increasingly adopted methodology in model-informed drug development. Now in its tenth year, the summit will unite industry innovators, academics, and thought leaders to explore how computational modeling is bridging biology and pharmacology to predict clinical outcomes, inform first-in-human dose decisions, and accelerate drug development timelines. New this year, we will spotlight Certara’s emerging AI-enabled QSP platform that is enhancing predictive power, automating model refinement, and expanding the reach of mechanistic modeling. Highlights will include case studies demonstrating scalability across rare and neurodegenerative diseases, strategies for reducing reliance on animal models via non‑animal safety evaluation tools, and innovative applications like virtual patient populations and digital twins. Expect forward-looking discussions on how regulatory acceptance, AI‑integration, and rigorous mechanistic modeling are transforming QSP from a niche methodology into a foundational pillar across R&D.