Jennypher Mudunuru, PH.D, GSK
personal info
Jennypher Mudunuru, Ph.D., is a highly motivated Modeling Scientist in DMPK (Drug Metabolism and Pharmacokinetics) at GSK (GlaxoSmithKline). With a strong background in pharmacokinetics and proficiency in DMPK and ADME (Absorption, Distribution, Metabolism, Excretion), she specializes in PBPK modeling and simulations. She earned her Master’s in Pharmaceutics and a Ph.D. in Pharmaceutics and Drug Design from Long Island University, focusing her doctoral dissertation on Drug Metabolism and Pharmacokinetic assessment for an Oncology small molecule company’s IND enabling studies.
As part of her doctoral research, she has designed and executed safety and efficacy studies in pre-clinical species, conducted in vitro metabolism studies, and demonstrated expertise in cancer cell culture and tumor xenograft models for PK and PD endpoints. In her current role at GSK, she serves as the lead PBPK Modeler on multiple programs, specializing in Model Informed Drug Development – involving DDIs, altered PK due to disease states, and supporting clinical study designs particularly in Oncology and Immunology.
She has played a crucial role as the lead modeler on pre-candidate selection projects, supporting First-Time in Human dose milestones for candidate selection. Jennypher has led various projects, showcasing her expertise in drug-drug interactions and special populations. Her current focus involves building and utilizing special populations for a more realistic estimation of pharmacokinetics and drug-drug interactions in both small and large molecules.
Jennypher has significantly influenced multiple regulatory submissions related to First-Time in Human studies and drug-drug interactions from Phase 1 to post market approval questions. Her research contributions have been presented at prestigious conferences, including IQ Consortium, AAPS, Gordon Research Conference, Simcyp Annual Consortium, and AACR. She has received multiple high-performance and individual awards at GSK and external awards for her impactful work and overall contributions to the field.